CF CompleteTM |
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Evaluates the entire CF gene coding sequence |
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Benefits of CF Complete™ – the Most Advanced
Cystic Fibrosis Test
| • | Automated, full length sequencing of the CF gene |
| • | Detects 99% of the 1,006 currently known CF mutations |
| • | Detects CF mutations not found in routine screening |
| • | Identifies rare familial CF mutations |
| • | Complements, but does not replace, the routine CF screening panel recommended by ACMG and ACOG. |
Clinical Summary
| • | Cystic fibrosis is an autosomal recessive disease that affects approximately 1 in 2,500 Caucasians of Northern European descent. It also occurs in other ethnic groups, but at a lower incidence. |
| • | To date, more than 1,000 disease-causing mutations have been identified. Routine carrier screening detects 25 of these mutations and 6 polymorphisms, identifying a maximum of 97% of carriers (Ashkenazi Jewish population). In other populations, the detection rate can be substantially lower (eg, only 57% in the Hispanic-American population). |
| • | Use of the CF Complete™ test, however, can dramatically increase the CF detection rate because it detects all but 13 of the currently known 1,006 mutations. Nevertheless, the CF Complete™ test should not replace the general carrier screen test. Rather, the CF Complete™ test should be used to identify rare familial mutations in obligate CF carriers when they have tested negative in the routine screening test. |
| • | CF Complete™ should also be used to identify a rare mutation in a CF-affected person when that person has tested negative in the routine screen. |
The Industry Leader in Genetic Testing
Upholding a tradition of innovation, Quest Diagnostics is the first clinical laboratory to offer testing that sequences the entire cystic fibrosis gene. CF Complete™ is part of a full range of cystic fibrosis testing services that includes both screening and diagnostic tests.
Quest Diagnostics Genetics Center
Physicians, if you need assistance with any genetic test, the Quest Diagnostics Genetics Center is ready to assist you. A dedicated genetics customer service professional will answer your question or, if appropriate, connect you with one of our:
| • | Seventeen Directors certified by the American Board of Medical Genetics, |
| • | Eight genetic counselors certified by the American Board of Genetic Counseling, or |
| • | Two academic associates who are thought leaders from academic medical centers. |
Contact the Genetics Center toll-free, at
Online Resources for Healthcare Professionals
| • | Access our online Test Menu to obtain test ordering codes and specimen requirements. |
| • | Visit our Interpretive Guide for information relating to genetic test selection, utilization, and interpretation. |
| • | Learn more about our genetic testing capabilities. |
| • | Simplify test ordering and results reporting with our connectivity solutions. |
Online Test Information for Your Patients
Your patients can learn about health conditions and laboratory tests in our online Patient Health Library. The library is founded on evidence-based information, and includes topics such as:
Contact a Quest Diagnostics Sales Representative,
learn more about our testing services, and become a client
| • | Contact a physician sales representative |
| • | Contact a hospital sales representative or learn about our complete hospital offerings |
